Analysis of Blood Transfusion Reactions in Pediatric Populations

By
Elizabeth F. Stone
Daniel Chacreton
Alexandra Jimenez
Shannon Kelly
Ruchika Goel
Jeanne E. Hendrickson
Marianne E. Nellis
Martha Sola-Visner
Oliver Karam
Ravi M. Patel
Sarah Vossoughi
Madhav Vissa
Sarah Wilson
Jeffrey J. VanWormer
Sylvia Titi Singer
Sara Bakhtary
Elliott P. Vichinsky
Naomi L.C. Luban
Cassandra D. Josephson
Matthew S. Karafin
NHLBI Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P)
April 27, 2026
0 min

1

Pediatric patients experience higher rates of transfusion reactions compared to adults, particularly febrile nonhemolytic and allergic reactions.
2

A multicenter, prospective study was conducted to analyze pediatric transfusion reactions across eight hospitals in the US from 2019 to 2023.
3

The study aimed to standardize data collection on transfusion reactions, addressing gaps in current knowledge and reporting practices.
4

Data were collected on various demographic and clinical factors to explore variations in reaction rates among pediatric patients.
5

Findings from this study may lead to improved transfusion safety guidelines and targeted prevention strategies for pediatric patients.

Jama Network Open

by Elizabeth F. Stone, Daniel Chacreton, Alexandra Jimenez, Shannon Kelly, Ruchika Goel, Jeanne E. Hendrickson, Marianne E. Nellis, Martha Sola-Visner, Oliver Karam, Ravi M. Patel, Sarah Vossoughi, Madhav Vissa, Sarah Wilson, Jeffrey J. VanWormer, Sylvia Titi Singer, Sara Bakhtary, Elliott P. Vichinsky, Naomi L.C. Luban, Cassandra D. Josephson, Matthew S. Karafin, NHLBI Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P)
April 27, 2026

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