Identification of a Unique cyp51A Mutation in Aspergillus fumigatus from a Patient with Systemic Lupus Erythematosus and Limited Systemic Sclerosis: The First Report of Acquired Azole Resistance in Colombia

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A unique cyp51A mutation in Aspergillus fumigatus was identified in a patient with systemic lupus erythematosus and limited systemic sclerosis in Colombia.
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The patient developed invasive aspergillosis due to azole-resistant A. fumigatus after being treated with voriconazole for chronic pulmonary aspergillosis.
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The identified cyp51A gene variant TR46/F46Y/Y121F/M172V/E427K contributes to the understanding of drug-resistant polymorphisms in A. fumigatus.
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This case represents the first report of acquired azole resistance in Colombia, highlighting the emerging issue of antifungal resistance in South America.
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Despite treatment, the patient succumbed to respiratory failure, underscoring the high mortality associated with invasive aspergillosis in immunocompromised individuals.

Bmc Infectious Diseases

by Carlos Morales-Pertuz, Miguel Ángel Vanegas, Ximena Castañeda-Luquerna, Eliana Maldonado, Jorge Alberto Carrillo, Anghie Katherine López-Valencia, Carolina Firacative
March 2, 2026

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