CD4/CD8 ratio is associated with structural reorganization of vaccine-induced immune responses in people living with HIV - Takeaways - MDSpire

CD4/CD8 ratio is associated with structural reorganization of vaccine-induced immune responses in people living with HIV

  • By

  • Faith Jessica Paran

  • Mizue Saita

  • Rieko Oyama

  • Namiko Nomura

  • Kaori Saito

  • Abdullah Khasawneh

  • Pei Gao

  • Songling Li

  • Hendra Saputra Ismanto

  • Noriyo Nagata

  • Naoko Iwata

  • Yasushi Okazaki

  • Tadaki Suzuki

  • Yuki Uehara

  • Kazuhisa Takahashi

  • Daron M Standley

  • Yoko Tabe

  • Toshio Naito

  • June 1, 2026

  • 0 min

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  • 1

    People living with HIV (PLWH) experience persistent immune activation and low-grade inflammation despite effective antiretroviral therapy.

  • 2

    The study analyzed immune responses in PLWH before and after mRNA vaccination, focusing on the CD4/CD8 ratio as a marker of immune health.

  • 3

    Distinct immune states were observed in PLWH stratified by CD4/CD8 ratio, with low ratios showing broad transcriptional dysregulation.

  • 4

    Low CD4/CD8 ratio groups exhibited increased monocyte-specific protein–protein interaction connectivity and reduced clonotype diversity.

  • 5

    Vaccine-induced immune responses in PLWH are influenced by network-level organization associated with CD4/CD8 ratio-defined immune states.

Original Source(s)

CD4/CD8 ratio is associated with structural reorganization of vaccine-induced immune responses in people living with HIV

  • by Faith Jessica Paran, Mizue Saita, Rieko Oyama, Namiko Nomura, Kaori Saito, Abdullah Khasawneh, Pei Gao, Songling Li, Hendra Saputra Ismanto, Noriyo Nagata, Naoko Iwata, Yasushi Okazaki, Tadaki Suzuki, Yuki Uehara, Kazuhisa Takahashi, Daron M Standley, Yoko Tabe, Toshio Naito

  • June 1, 2026

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