Bone Material Strength Index Is Low in Patients With Cushing's Syndrome Even After Long-term Remission - Takeaways - MDSpire

Bone Material Strength Index Is Low in Patients With Cushing's Syndrome Even After Long-term Remission

  • By

  • Manuela Schoeb

  • Paula J C Sintenie

  • Leontine E H Bakker

  • Nienke R Biermasz

  • Femke M van Haalen

  • Michiel F Nijhoff

  • Friso de Vries

  • Elizabeth M Winter

  • Alberto M Pereira

  • Natasha M Appelman-Dijkstra

  • November 20, 2024

  • 0 min

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  • 1

    Cushing's syndrome leads to decreased bone mineral density and increased fracture risk, persisting even after long-term remission.

  • 2

    Bone material strength index (BMSi) was significantly lower in Cushing's syndrome patients compared to matched controls despite similar BMD.

  • 3

    The study involved 60 Cushing's syndrome patients and 60 matched controls, assessing bone material properties using impact microindentation.

  • 4

    BMSi in Cushing's syndrome patients correlated negatively with body mass index but was not linked to fracture presence or hydrocortisone use.

  • 5

    Altered bone material properties in Cushing's syndrome may contribute to persistent bone fragility, highlighting the need for comprehensive fracture risk assessment.

Original Source(s)

Bone Material Strength Index Is Low in Patients With Cushing's Syndrome Even After Long-term Remission

  • by Manuela Schoeb, Paula J C Sintenie, Leontine E H Bakker, Nienke R Biermasz, Femke M van Haalen, Michiel F Nijhoff, Friso de Vries, Elizabeth M Winter, Alberto M Pereira, Natasha M Appelman-Dijkstra

  • November 20, 2024

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