A rare case of isovaleric acidemia and schizophrenia: a case report

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Isovaleric acidemia (IVA) is a metabolic disorder caused by a deficiency in isovaleryl-CoA dehydrogenase, leading to impaired leucine metabolism.
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The patient, diagnosed with both IVA and schizophrenia, exhibited symptoms of schizophrenia starting at age 18, including delusions and social withdrawal.
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Treatment for the patient included various antipsychotics and mood stabilizers, with adjustments made due to side effects and persistent symptoms.
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The case highlights a potential link between metabolic dysregulation in IVA and the pathophysiological mechanisms underlying schizophrenia.
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This case study provides a novel perspective on the complex etiology of schizophrenia, suggesting shared processes with metabolic disorders like IVA.

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