Signal, not noise: learning to measure emphysema beyond the −950 HU threshold - Takeaways - MDSpire
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Beyond the −950 HU Threshold: Advancing Emphysema Measurement Techniques

  • By

  • Hongseok Ko

  • Jiyoung Song

  • Taehee Lee

  • September 11, 2026

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  • 1

    Spirometry cannot delineate emphysema, making CT the sole practical method for quantifying lung parenchymal destruction in vivo.

  • 2

    The LAA-950 metric, based on lung voxel attenuation, has limitations due to measurement error exceeding annual emphysema progression.

  • 3

    Deep-learning-based segmentation shows promise in improving emphysema measurement accuracy compared to traditional density thresholding.

  • 4

    A virtual imaging trial produced a validated reference standard, enabling improved reproducibility of emphysema measurements.

  • 5

    Future priorities include evaluating photon-counting CT, longitudinal validation of AI-derived measurements, and adapting algorithms for clinical practice.

Original Source(s)

Signal, not noise: learning to measure emphysema beyond the −950 HU threshold

  • by Hongseok Ko, Jiyoung Song, Taehee Lee

  • September 11, 2026

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