Association of serum growth differentiation factor 11 with asthma severity, inflammation, and airway remodeling in pediatric patients - Takeaways - MDSpire

Relationship Between Serum Growth Differentiation Factor 11 Levels and Asthma Severity, Inflammatory Responses, and Airway Remodeling in Children

  • By

  • Yanran Che

  • Ji Yang

  • July 20, 2026

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  • 1

    Children with asthma have significantly lower serum GDF11 levels compared to healthy controls, with further reductions during exacerbations.

  • 2

    Higher serum GDF11 levels are independently associated with reduced odds of asthma exacerbation, with an odds ratio of 0.879.

  • 3

    Serum GDF11 levels positively correlate with pulmonary function parameters and inversely correlate with inflammatory markers and eosinophil counts.

  • 4

    ROC analysis indicates that serum GDF11 can accurately distinguish asthma exacerbations, with an AUC of 0.839.

  • 5

    The study highlights the potential role of serum GDF11 as a biomarker for asthma severity and exacerbation risk in pediatric patients.

Original Source(s)

Association of serum growth differentiation factor 11 with asthma severity, inflammation, and airway remodeling in pediatric patients

  • by Yanran Che, Ji Yang

  • July 20, 2026

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