Relationship Between Serum Growth Differentiation Factor 11 Levels and Asthma Severity, Inflammatory Responses, and Airway Remodeling in Children

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Children with asthma have significantly lower serum GDF11 levels compared to healthy controls, with further reductions during exacerbations.
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Higher serum GDF11 levels are independently associated with reduced odds of asthma exacerbation, with an odds ratio of 0.879.
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Serum GDF11 levels positively correlate with pulmonary function parameters and inversely correlate with inflammatory markers and eosinophil counts.
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ROC analysis indicates that serum GDF11 can accurately distinguish asthma exacerbations, with an AUC of 0.839.
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The study highlights the potential role of serum GDF11 as a biomarker for asthma severity and exacerbation risk in pediatric patients.

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