Cushing’s syndrome and early growth hormone hypersecretion in a child with Carney complex: a case report

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Carney complex (CNC) is a rare autosomal dominant syndrome associated with multiple endocrine and non-endocrine tumors.
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A 5-year-old girl with CNC presented with symptoms of Cushing's syndrome and was diagnosed with ACTH-independent Cushing's syndrome.
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Genetic testing confirmed a PRKAR1A gene mutation in the patient and her father, linking their conditions to CNC.
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The patient later exhibited accelerated growth velocity and elevated IGF-1 levels, indicating early growth hormone hypersecretion.
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This case emphasizes the need for genetic testing and monitoring for growth hormone excess in pediatric patients with CNC.

Frontiers In Endocrinology

by Gaia Pietropaolo, Adalgisa Festa, Giulio Rivetti, Federica Messa, Giovanni Di Iorio, Antonella Klain, Valeria Pellino, Daniela Cioffi, Rosario Ferrigno, Maria Cristina Savanelli, Emanuele Miraglia Del Giudice, Anna Grandone
June 29, 2026

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