Mitochondrial DNA Methylation as a Predictor of Immunotherapy Outcomes and Prognosis in Lung Adenocarcinoma: Insights from Single-Cell RNA Sequencing and Machine Learning Approaches

1

Lung adenocarcinoma (LUAD) is the most prevalent lung cancer subtype, contributing significantly to cancer-related mortality globally.
2

Mitochondrial DNA methylation (MTDM) is emerging as a crucial factor influencing gene expression and cellular function in LUAD.
3

Single-cell RNA sequencing (scRNA-Seq) is vital for understanding the tumor microenvironment and identifying prognostic markers in LUAD.
4

A machine learning-based prognostic model was developed using mitochondrial gene expression and clinical features to predict LUAD outcomes.
5

Differentially expressed mitochondrial DNA methylation-related genes (DEMTDMRGs) were identified as significant prognostic indicators in LUAD.

Bmc Cancer

by Jian Ding, Gang Cheng, Qian Xue, Weizhen Guo, Yikun Cheng, Cheng Yang, Jiabing Tong, Zegeng Li, Yating Gao
February 10, 2026

1