Investigating HPA Axis Function in Women Undergoing Chemotherapy with Adjunctive High-Dose Dexamethasone: A Prospective Pilot Study - Takeaways - MDSpire

Investigating HPA Axis Function in Women Undergoing Chemotherapy with Adjunctive High-Dose Dexamethasone: A Prospective Pilot Study

  • By

  • Elżbieta Turska

  • Krzysztof Lewandowski

  • Igor Symonowicz

  • Magdalena Kobus

  • Wojciech Horzelski

  • Tomasz Kubiatowski

  • Justyna Marchewka-Długońska

  • Ewa Kalinka

  • April 23, 2026

  • 0 min

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  • 1

    The study evaluated HPA axis function in 47 women with breast cancer receiving high-dose dexamethasone during chemotherapy.

  • 2

    Morning cortisol and ACTH concentrations showed a downward trend during treatment, but no significant changes were observed.

  • 3

    Findings highlight the limitations of single cortisol measurements and the need for longitudinal assessment of adrenal function.

  • 4

    The study emphasizes the risk of glucocorticoid-induced adrenal insufficiency in oncology patients undergoing chemotherapy.

  • 5

    Further research is needed to establish effective methods for evaluating HPA axis function during intermittent glucocorticoid exposure.

Original Source(s)

Investigating HPA Axis Function in Women Undergoing Chemotherapy with Adjunctive High-Dose Dexamethasone: A Prospective Pilot Study

  • by Elżbieta Turska, Krzysztof Lewandowski, Igor Symonowicz, Magdalena Kobus, Wojciech Horzelski, Tomasz Kubiatowski, Justyna Marchewka-Długońska, Ewa Kalinka

  • April 23, 2026

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