Elevated serum plasminogen activator inhibitor-1 is associated with seizure burden, drug resistance, and neuroinflammatory markers in pediatric epilepsy - Takeaways - MDSpire

Elevated serum plasminogen activator inhibitor-1 is associated with seizure burden, drug resistance, and neuroinflammatory markers in pediatric epilepsy

  • By

  • Xiao Xiao

  • Xiaoyan Shi

  • Jun Feng

  • Xinyu Zhou

  • Manli Wang

  • Bingbing Zhang

  • Chen Xu

  • Jihong Tang

  • July 14, 2026

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  • 1

    Serum PAI-1 levels were significantly higher in pediatric epilepsy patients compared to healthy controls, indicating a potential biomarker for the condition.

  • 2

    PAI-1 concentrations positively correlated with seizure frequency and were elevated in patients with drug-resistant epilepsy.

  • 3

    PAI-1 demonstrated strong independent association with monthly seizure frequency, suggesting its role in seizure burden assessment.

  • 4

    Higher PAI-1 levels correlated with neuroinflammatory markers and blood-brain barrier disruption, linking it to underlying epilepsy mechanisms.

  • 5

    The study suggests PAI-1 may serve as a risk-stratification biomarker for identifying children with higher disease burden in epilepsy.

Original Source(s)

Elevated serum plasminogen activator inhibitor-1 is associated with seizure burden, drug resistance, and neuroinflammatory markers in pediatric epilepsy

  • by Xiao Xiao, Xiaoyan Shi, Jun Feng, Xinyu Zhou, Manli Wang, Bingbing Zhang, Chen Xu, Jihong Tang

  • July 14, 2026

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