Refractory mastoiditis as the initial manifestation of granulomatosis with polyangiitis:a case report and literature review - Takeaways - MDSpire
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Initial Presentation of Granulomatosis with Polyangiitis: A Case of Refractory Mastoiditis and Review of Existing Literature

  • By

  • Xinying Cui

  • Chunchao Wang

  • Jingchun Jin

  • June 29, 2026

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  • 1

    Granulomatosis with Polyangiitis (GPA) is an ANCA-associated vasculitis affecting the respiratory tracts and kidneys.

  • 2

    Isolated destructive mastoiditis as the initial manifestation of GPA is rare and can lead to misdiagnosis.

  • 3

    A 69-year-old female with refractory mastoiditis was diagnosed with GPA after showing no response to antibiotics.

  • 4

    Serological testing revealed elevated PR3-ANCA levels, and chest CT showed multiple bilateral pulmonary nodules.

  • 5

    The patient was treated with methylprednisolone and rituximab, leading to improvement in symptoms and PR3-ANCA titers.

Original Source(s)

Refractory mastoiditis as the initial manifestation of granulomatosis with polyangiitis:a case report and literature review

  • by Xinying Cui, Chunchao Wang, Jingchun Jin

  • June 29, 2026

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