Genetic Link Between HLA-A*32:01 and Lamotrigine-Related DRESS: Insights for Clinical Practice

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HLA-A*32:01 carriage was found in 41.4% of DRESS cases and 4.1% of lamotrigine-tolerant controls, indicating a strong association with increased DRESS risk.
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Current screening practices focus on carbamazepine risk alleles, leaving a gap in identifying lamotrigine-related hypersensitivity risks.
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Concurrent acute liver injury occurred in 69.0% of DRESS cases, suggesting hepatic injury is a common manifestation of lamotrigine hypersensitivity.
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HLA-A*32:01 screening's clinical utility is uncertain due to low positive predictive values and the allele's presence in only 41.4% of DRESS cases.
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Further research is needed to validate HLA-A*32:01 screening across diverse populations and assess its impact on clinical outcomes.

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