Tackling neuronal stress and neuroinflammation to prevent side effects of brain radiotherapy - Takeaways - MDSpire

Tackling neuronal stress and neuroinflammation to prevent side effects of brain radiotherapy

  • By

  • Lara Kular

  • Michael Gubanski

  • Jiri Bartek

  • Maja Jagodic

  • July 23, 2025

  • 0 min

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  • 1

    Radiation therapy is essential for treating brain tumors but poses risks of cognitive decline and vascular complications.

  • 2

    Newer radiation techniques can cause pseudoprogression, complicating patient follow-up and leading to unnecessary interventions.

  • 3

    Irradiation induces widespread DNA methylation changes in healthy brain tissue, affecting gene regulation related to neuroinflammation.

  • 4

    Neurons in irradiated areas exhibit markers of senescence and inflammation, impacting communication with glial and immune cells.

  • 5

    Cerebral organoid models reveal early DNA methylation changes post-irradiation, providing insights into the underlying mechanisms.

Original Source(s)

Tackling neuronal stress and neuroinflammation to prevent side effects of brain radiotherapy

  • by Lara Kular, Michael Gubanski, Jiri Bartek, Maja Jagodic

  • July 23, 2025

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