A distinct population of Low-Density Granulocytes with unique features associated with subclinical vascular alterations in Systemic Lupus Erythematosus - Takeaways - MDSpire

A distinct population of Low-Density Granulocytes with unique features associated with subclinical vascular alterations in Systemic Lupus Erythematosus

  • By

  • Tobío-Parada, Uxía

  • Rodríguez-Carrio, Javier

  • Martínez-Zapico, Aleida

  • Pérez-Álvarez, Angel I.

  • Suárez-Díaz, Silvia

  • Suárez, Ana

  • López, Patricia

  • May 5, 2026

  • 0 min

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  • 1

    Low-density granulocytes (LDGs) are implicated in the pathogenesis of Systemic Lupus Erythematosus (SLE) and associated vascular complications.

  • 2

    A distinct myeloid subset, characterized as nAPC-like neutrophils, was identified in SLE patients, separate from standard LDG/monocyte populations.

  • 3

    nAPC-like neutrophils correlated with Th1, Th17, and Treg cells, as well as SLEDAI and anti-dsDNA titers, indicating their role in immune dysregulation.

  • 4

    Increased nAPC-like neutrophils were found in SLE patients and controls with cardiovascular risk factors or clinical/subclinical cardiovascular disease.

  • 5

    A minor CD16dim_nAPC-like subset, suggestive of immaturity, was expanded in SLE and correlated with serum IL-6 and BLyS levels.

Original Source(s)

A distinct population of Low-Density Granulocytes with unique features associated with subclinical vascular alterations in Systemic Lupus Erythematosus

  • by Tobío-Parada, Uxía , Rodríguez-Carrio, Javier , Martínez-Zapico, Aleida , Pérez-Álvarez, Angel I., Suárez-Díaz, Silvia , Suárez, Ana , López, Patricia

  • May 5, 2026

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