Case Report: Sequential mNGS captures fatal HSV-1 reactivation after intestinal obstruction-associated ARDS in a 91-year-old - Takeaways - MDSpire
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Case Study: Fatal Reactivation of HSV-1 Detected by Sequential mNGS Following ARDS Induced by Intestinal Obstruction in a 91-Year-Old Patient

  • By

  • Jiahuan Li

  • Xiaofei Li

  • Huafang Zhong

  • Li Wang

  • Ling Yue

  • September 14, 2026

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  • 1

    A 91-year-old patient developed ARDS following intestinal obstruction and experienced fatal reactivation of HSV-1.

  • 2

    Sequential metagenomic next-generation sequencing (mNGS) was used to monitor pathogen evolution throughout the patient's illness.

  • 3

    Despite aggressive treatment, including broad-spectrum antibiotics and mechanical ventilation, the patient progressed to multiple organ dysfunction.

  • 4

    The initial mNGS assay detected no pathogens, but subsequent tests identified predominant HSV-1 alongside other pathogens.

  • 5

    This case highlights the challenges of diagnosing and managing critically ill elderly patients with complex infections.

Original Source(s)

Case Report: Sequential mNGS captures fatal HSV-1 reactivation after intestinal obstruction-associated ARDS in a 91-year-old

  • by Jiahuan Li, Xiaofei Li, Huafang Zhong, Li Wang, Ling Yue

  • September 14, 2026

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