Post-stroke insomnia: multidimensional mechanisms, clinical heterogeneity, and toward mechanism-informed, objectively quantified management

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Post-stroke insomnia (PSI) is common among stroke survivors and is linked to reduced rehabilitation participation and quality of life.
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PSI results from complex interactions of neurobiological and psychosocial mechanisms, including neurotransmitter disturbances and neuroinflammation.
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Clinical management of PSI often relies on general insomnia protocols, which may not adequately address the unique needs of stroke patients.
4

Variability in PSI symptoms and treatment outcomes is influenced by stroke subtype, comorbidities, and individual patient factors.
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A mechanism-informed strategy for PSI treatment emphasizes objective sleep evaluation and tailored interventions based on patient-specific factors.

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