Proliferative glomerulonephritis with monoclonal immunoglobulin IgG1-κ deposition in a patient with type 1 diabetes: a case report and literature review - Takeaways - MDSpire

Proliferative glomerulonephritis with monoclonal immunoglobulin IgG1-κ deposition in a patient with type 1 diabetes: a case report and literature review

  • By

  • Xi Li

  • Xiaoyan Zhang

  • Xinjun Dai

  • Yan Zhang

  • Tian Lan

  • Jian Li

  • Minghui Wu

  • Tianhang Jia

  • Jie Li

  • June 15, 2026

  • 0 min

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  • 1

    Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is characterized by edema, proteinuria, and renal insufficiency.

  • 2

    A 30-year-old woman with a 19-year history of type 1 diabetes presented with nephrotic-range proteinuria and acute renal failure.

  • 3

    Renal biopsy revealed monoclonal IgG1-κ deposits, with immunofluorescence showing granular deposits along glomerular capillary loops.

  • 4

    The patient was treated with prednisone and cyclophosphamide, showing a good initial response but later required long-term dialysis.

  • 5

    Diagnosis of PGNMID necessitates renal biopsy and comprehensive testing, especially in patients with diabetes and renal dysfunction.

Original Source(s)

Proliferative glomerulonephritis with monoclonal immunoglobulin IgG1-κ deposition in a patient with type 1 diabetes: a case report and literature review

  • by Xi Li, Xiaoyan Zhang, Xinjun Dai, Yan Zhang, Tian Lan, Jian Li, Minghui Wu, Tianhang Jia, Jie Li

  • June 15, 2026

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