Qualitative assessment of nasopharyngeal aspirates as an alternative to tracheal aspirates in extremely preterm infants - Takeaways - MDSpire

Qualitative assessment of nasopharyngeal aspirates as an alternative to tracheal aspirates in extremely preterm infants

  • By

  • Fernando Garrido-Muñoz

  • Alejandro Fernández-Vega

  • Rebeca Gregorio-Hernández

  • Alberto Trujillo-Fagundo

  • Almudena Alonso-Ojembarrena

  • June 10, 2026

  • 0 min

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  • 1

    Nasopharyngeal aspirates (NPAs) show potential as a noninvasive alternative to tracheal aspirates (TAs) for respiratory biomarker research in preterm infants.

  • 2

    The study analyzed paired NPA and TA samples from 1-week-old neonates, revealing significant similarities and differences in their proteomic profiles.

  • 3

    649 shared proteins were identified, with 60.4% specific to lung cells related to preterm lung pathologies, highlighting the relevance of NPAs.

  • 4

    NPA proteins were enriched in terms related to the epithelium, while TA proteins remained specific to lung tissue, indicating distinct biological insights.

  • 5

    This research supports the use of NPAs in studying respiratory diseases, potentially improving patient recruitment and reducing stress in extremely preterm infants.

Original Source(s)

Qualitative assessment of nasopharyngeal aspirates as an alternative to tracheal aspirates in extremely preterm infants

  • by Fernando Garrido-Muñoz, Alejandro Fernández-Vega, Rebeca Gregorio-Hernández, Alberto Trujillo-Fagundo, Almudena Alonso-Ojembarrena

  • June 10, 2026

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