The association between the triglyceride-glucose index and diabetic peripheral neuropathy: a systematic review and meta-analysis - Takeaways - MDSpire
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Examining the Link Between the Triglyceride-Glucose Index and Diabetic Peripheral Neuropathy: A Comprehensive Review and Meta-Analysis

  • By

  • Xin Gu

  • Maoying Wei

  • Chan Wu

  • Aijing Li

  • Anning Sun

  • Jingyi Guo

  • Haoshuo Wang

  • Churan Wang

  • Yincheng Li

  • Qingyi Zhu

  • Yanbing Gong

  • September 4, 2026

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  • 1

    Diabetic peripheral neuropathy (DPN) is a common complication of type 2 diabetes mellitus (T2DM), affecting approximately 30% of patients.

  • 2

    The triglyceride-glucose (TyG) index serves as a surrogate measure of insulin resistance and is associated with various diabetic complications.

  • 3

    A meta-analysis of 14 studies found that elevated TyG index values correlate with increased DPN risk, with a pooled odds ratio of 2.614.

  • 4

    The association between TyG index and DPN risk was significant across most subgroups, except for the non-China subgroup.

  • 5

    Higher TyG values in T2DM patients are linked to greater DPN risk, but further validation is needed to establish a causal relationship.

Original Source(s)

The association between the triglyceride-glucose index and diabetic peripheral neuropathy: a systematic review and meta-analysis

  • by Xin Gu, Maoying Wei, Chan Wu, Aijing Li, Anning Sun, Jingyi Guo, Haoshuo Wang, Churan Wang, Yincheng Li, Qingyi Zhu, Yanbing Gong

  • September 4, 2026

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