Serial lactate–procalcitonin interaction identifies a high-risk phenotype in 24-h conditional survivors of post-cardiac arrest syndrome: a CART-based analysis - Takeaways - MDSpire

Serial lactate–procalcitonin interaction identifies a high-risk phenotype in 24-h conditional survivors of post-cardiac arrest syndrome: a CART-based analysis

  • By

  • Ali Muhittin Tasdogan

  • Stemi Taha Polat

  • Emin Erdem Kaya

  • Ufuk Ozgur Balica

  • Yavuz Saygili

  • July 1, 2026

  • 0 min

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  • 1

    The study analyzed 158 24-hour conditional survivors of post-cardiac arrest syndrome (PCAS) to investigate metabolic and inflammatory responses.

  • 2

    In-hospital mortality was 70.9%, with non-survivors showing higher rates of non-shockable rhythms and longer CPR durations.

  • 3

    Persistent hyperlactatemia at 48 hours was identified as a significant independent predictor of mortality with an odds ratio of 1.92.

  • 4

    CART analysis revealed a high-risk phenotype characterized by T0 lactate >5 mmol/L and T24 PCT > 5.5 ng/mL, associated with 92% mortality risk.

  • 5

    The CART model demonstrated excellent calibration and comparable discrimination to logistic regression for predicting mortality.

Original Source(s)

Serial lactate–procalcitonin interaction identifies a high-risk phenotype in 24-h conditional survivors of post-cardiac arrest syndrome: a CART-based analysis

  • by Ali Muhittin Tasdogan, Stemi Taha Polat, Emin Erdem Kaya, Ufuk Ozgur Balica, Yavuz Saygili

  • July 1, 2026

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