Single-cell analysis reveals KLF10-high macrophages induced by glioblastoma cells are associated with tumor progression - Takeaways - MDSpire

Single-cell profiling identifies KLF10-enriched macrophages driven by glioblastoma cells linked to tumor advancement

  • By

  • Xiaodong Zhang

  • Caiping Chen

  • Qianya Fan

  • Sheng Chen

  • Duanzheng Cao

  • Zhonglin Hu

  • Yejun Zhou

  • Jinfang Xu

  • Delin Wang

  • July 20, 2026

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  • 1

    Glioblastoma is the most common and aggressive primary malignant tumor of the adult central nervous system, with a high recurrence rate.

  • 2

    Tumor-associated macrophages (TAMs) play critical roles in glioblastoma recurrence, but their characteristics in recurrent cases are not well defined.

  • 3

    A five-gene prognostic signature including KLF10 was identified, with high KLF10 expression predicting poor prognosis in glioblastoma.

  • 4

    KLF10 expression was associated with various clinicopathological features, including WHO grade and molecular subtype.

  • 5

    In vitro studies showed that KLF10-overexpressing macrophages increased glioblastoma cell proliferation, migration, and invasion.

Original Source(s)

Single-cell analysis reveals KLF10-high macrophages induced by glioblastoma cells are associated with tumor progression

  • by Xiaodong Zhang, Caiping Chen, Qianya Fan, Sheng Chen, Duanzheng Cao, Zhonglin Hu, Yejun Zhou, Jinfang Xu, Delin Wang

  • July 20, 2026

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