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1
The study compared serum GDF15 concentrations in 23 preterm-born children with reduced renal function, 83 with normal renal function, and 17 term-born children.
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2
Serum GDF15 concentrations were significantly higher in both preterm-born groups than in term-born children, with no significant difference between the preterm groups.
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3
Across all participants, serum GDF15 was not significantly correlated with eGFRcr (ρ = −0.15; P = .10).
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4
In the reduced renal function group, GDF15 was inversely correlated with eGFRcr, but the association was no longer statistically significant after excluding the participant with the lowest eGFRcr.
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5
The single-center exploratory study had a small sample and lacked concurrent inflammatory and oxidative stress marker measurements, limiting evaluation of mechanisms and clinical relevance.
