Trained immunity as a systemic bridge: the liver-gut-immune-oral axis in the comorbidity of chronic liver disease and periodontitis - Takeaways - MDSpire

Trained immunity as a systemic bridge: the liver-gut-immune-oral axis in the comorbidity of chronic liver disease and periodontitis

  • By

  • Xiang Li

  • Guodong Lv

  • Daolang Yuan

  • Jun Hu

  • Wenrong Lou

  • Yulin Tu

  • Jing Zhou

  • Rong Qin

  • June 4, 2026

  • 0 min

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  • 1

    Trained immunity (TI) enables innate immune cells to acquire long-term functional memory through metabolic and epigenetic reprogramming.

  • 2

    The review proposes a 'Liver-Gut-Immune-Oral Axis' linking chronic liver disease and periodontitis through TI mechanisms.

  • 3

    Liver-gut dysfunction can induce hyper-reactive monocytes that exacerbate periodontal inflammation, illustrating a forward pathway.

  • 4

    Conversely, periodontal pathogens can reprogram immune cells, accelerating liver disease progression, representing a reverse pathway.

  • 5

    The validity of the proposed axis as an integrated biological system requires direct experimental validation.

Original Source(s)

Trained immunity as a systemic bridge: the liver-gut-immune-oral axis in the comorbidity of chronic liver disease and periodontitis

  • by Xiang Li, Guodong Lv, Daolang Yuan, Jun Hu, Wenrong Lou, Yulin Tu, Jing Zhou, Rong Qin

  • June 4, 2026

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