Prospective association between biological aging and risk of hospital-diagnosed MASLD: evidence from the UK Biobank - Takeaways - MDSpire

Prospective association between biological aging and risk of hospital-diagnosed MASLD: evidence from the UK Biobank

  • By

  • Xue Yang

  • Sicheng Li

  • Qingping Xue

  • Peijing Yan

  • Qian Li

  • Yi Gong

  • Xiayue Fan

  • Wenzhi Zhu

  • Shiyi Wu

  • Shanshan Zhang

  • Ko Willems van Dijk

  • Patrick C.N. Rensen

  • Ruifang Li-Gao

  • Yanan Wang

  • Ting Yao

  • June 17, 2026

  • 0 min

Share

  • 1

    Accelerated biological aging is significantly associated with hospital-diagnosed MASLD, with hazard ratios of 1.46 for PhenoAge and 1.35 for KDMAge.

  • 2

    The study analyzed data from 247,444 UK Biobank participants, with 3,254 developing hospital-diagnosed MASLD over a median follow-up of 13.7 years.

  • 3

    PhenoAge acceleration mediates the relationship between unhealthy lifestyle factors and MASLD, accounting for 11.4% to 25.5% of the associations.

  • 4

    KDMAge acceleration showed minimal mediation effects (≤2%) in the relationship between lifestyle factors and hospital-diagnosed MASLD.

  • 5

    Findings suggest that biological aging may play a crucial role in MASLD risk stratification and prevention strategies.

Original Source(s)

Prospective association between biological aging and risk of hospital-diagnosed MASLD: evidence from the UK Biobank

  • by Xue Yang, Sicheng Li, Qingping Xue, Peijing Yan, Qian Li, Yi Gong, Xiayue Fan, Wenzhi Zhu, Shiyi Wu, Shanshan Zhang, Ko Willems van Dijk, Patrick C.N. Rensen, Ruifang Li-Gao, Yanan Wang, Ting Yao

  • June 17, 2026

Related Content

Case Report: Focal nodular hyperplasia of the liver in an adolescent—a case report and literature review

Case Report: Allergic reaction following fecal microbiota transplantation in children with autism spectrum disorder: a report of two cases

DNA damage response inhibitors in pancreatic cancer: progress and challenges