Understanding the Role of Regulatory T Cells in the Immune Microenvironment of Multiple Myeloma and Its Clinical Implications

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Multiple Myeloma (MM) is a hematologic malignancy characterized by clonal plasma cell proliferation and significant immune microenvironment involvement.
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Regulatory T cells (Tregs) play a crucial role in the immunosuppressive tumor microenvironment, promoting immune evasion of MM cells.
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Tregs utilize mechanisms such as cytokine secretion and cell-to-cell interactions to inhibit effector T cell and NK cell functions.
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The MM microenvironment supports Treg proliferation and activation, contributing to tumor survival, metastasis, and drug resistance.
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Understanding Treg mechanisms in MM is essential for developing targeted therapeutic strategies to overcome immune suppression.

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