Reduced IgM natural autoantibody levels against heat shock proteins are associated with disease severity in juvenile idiopathic arthritis - Takeaways - MDSpire

Lowered IgM natural autoantibody concentrations targeting heat shock proteins correlate with severity of juvenile idiopathic arthritis

  • By

  • Bernadett Mosdósi

  • Vivien Mátis

  • Ádám Győri

  • Panna Peti

  • Szabina Erdő-Bonyár

  • Timea Berki

  • Diana Simon

  • July 17, 2026

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  • 1

    Natural autoantibodies (nAAbs) play a role in immune homeostasis and may be altered in autoimmune diseases like juvenile idiopathic arthritis (JIA).

  • 2

    The study measured serum levels of IgM and IgG nAbs against heat shock proteins in children with JIA in remission and healthy controls.

  • 3

    Significantly lower anti-Hsp60 and anti-Hsp70 IgM levels were found in patients with polyarticular JIA compared to those with oligoarticular forms.

  • 4

    No significant differences in anti-Hsp60 or anti-Hsp70 nAAb levels were observed between JIA patients and healthy controls or between treatment groups.

  • 5

    Reduced levels of natural IgM autoantibodies against Hsp60 and Hsp70 correlate with more severe JIA phenotypes during remission.

Original Source(s)

Reduced IgM natural autoantibody levels against heat shock proteins are associated with disease severity in juvenile idiopathic arthritis

  • by Bernadett Mosdósi, Vivien Mátis, Ádám Győri, Panna Peti, Szabina Erdő-Bonyár, Timea Berki, Diana Simon

  • July 17, 2026

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