Reduced left dorsolateral prefrontal activation and right inferior frontal de-oxygenation differ between psychotic and non−psychotic adolescent depression during verbal fluency - Takeaways - MDSpire

Reduced left dorsolateral prefrontal activation and right inferior frontal de-oxygenation differ between psychotic and non−psychotic adolescent depression during verbal fluency

  • By

  • Gang Liu

  • Yu Yang

  • Jie Liao

  • Yanping Feng

  • Sha Zhang

  • Yudiao Liang

  • June 2, 2026

  • 0 min

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  • 1

    Adolescents with major depressive disorder and psychotic symptoms (MDD-Psy) show greater clinical severity than those without psychosis (MDD-NonPsy).

  • 2

    Functional near-infrared spectroscopy revealed distinct hemodynamic responses in the left dorsolateral prefrontal cortex between MDD-Psy and MDD-NonPsy during verbal fluency tasks.

  • 3

    MDD-Psy adolescents exhibited negative deviations in hemodynamic responses at specific channels, while MDD-NonPsy showed positive deviations.

  • 4

    The right inferior frontal gyrus demonstrated significant differences in deoxygenation levels between the two groups, correlating with clinical severity scores.

  • 5

    The study highlights the potential for fNIRS-derived hemodynamic signatures to inform future research on neurobiological differentiation in adolescent depression.

Original Source(s)

Reduced left dorsolateral prefrontal activation and right inferior frontal de-oxygenation differ between psychotic and non−psychotic adolescent depression during verbal fluency

  • by Gang Liu, Yu Yang, Jie Liao, Yanping Feng, Sha Zhang, Yudiao Liang

  • June 2, 2026

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