A case analysis of Gitelman syndrome1 complicated with Sjögren’s disease - Takeaways - MDSpire

A case analysis of Gitelman syndrome1 complicated with Sjögren’s disease

  • By

  • Yuqi Tang

  • Sen Tian

  • Cong Xia

  • Yan Zhang

  • Qiaoding Dai

  • June 19, 2026

  • 0 min

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  • 1

    Sjögren’s disease and Gitelman syndrome both cause hypokalemia, complicating their differential diagnosis.

  • 2

    A 62-year-old female presented with fatigue, dry mouth, and refractory hypokalemia, leading to the diagnosis of both conditions.

  • 3

    Immunological tests confirmed Sjögren’s disease, while genetic analysis identified pathogenic mutations in SLC12A3, confirming Gitelman syndrome.

  • 4

    Combined therapy with potassium supplementation and hydroxychloroquine effectively resolved symptoms and stabilized potassium levels.

  • 5

    The case highlights the importance of genetic testing in patients with refractory hypokalemia to identify underlying hereditary disorders.

Original Source(s)

A case analysis of Gitelman syndrome1 complicated with Sjögren’s disease

  • by Yuqi Tang, Sen Tian, Cong Xia, Yan Zhang, Qiaoding Dai

  • June 19, 2026

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