Impact of an enhanced anti-infection prophylaxis strategy for pancreatoduodenectomy: a single centre analysis

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Pancreatoduodenectomy (PD) is the primary curative treatment for pancreatic head, distal bile duct, or ampullary tumors.
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Postoperative complications, including surgical site infections (SSI), occur in nearly half of PD patients, significantly impacting recovery.
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Enhanced anti-infection prophylaxis, including targeted antibiotics and extended intraoperative peritoneal lavage, aims to reduce SSI rates.
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The study analyzed 163 patients undergoing PD, comparing standard prophylaxis with an enhanced strategy based on local resistance patterns.
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The primary outcome measured was the incidence of septic complications within 90 days post-surgery, with secondary endpoints including morbidity and mortality.

Langenbeck's Archives Of Surgery

by Tina Groß, Felix Merboth, Anna Klimowa, Christoph Kahlert, Marius Distler, Jürgen Weitz, Thilo Welsch, Benjamin Müssle
October 15, 2024

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