Association between leptin gene polymorphisms and hematological metabolic parameters in obese Saudi adults - Takeaways - MDSpire

Association between leptin gene polymorphisms and hematological metabolic parameters in obese Saudi adults

  • By

  • Lamiaa Hamad Al-Jamea

  • Alexander Woodman

  • Rehab Yusuf Al-Ansari

  • Fatimah Salem Alayidh

  • Khalid Khalaf Alharbi

  • Nayef Saleh Al Ahmadi

  • Rashid Al-Jawair

  • Ibrahim Sahin

  • Shouq Saleh AlGhamdi

  • Emad Johar Al Johar

  • Jenifer Vecina Quiambao

  • Abdel Halim Deifalla

  • Yousef Mohammed Hawsawi

  • June 5, 2026

  • 0 min

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  • 1

    Obesity prevalence in Saudi Arabia exceeds 24.7%, significantly impacting public health and contributing to various comorbidities.

  • 2

    The study analyzed 202 Saudi adults, revealing significant hematological differences between obese and non-obese individuals.

  • 3

    Obese participants exhibited elevated white blood cell and platelet counts, alongside decreased red blood cell counts and indices.

  • 4

    Two genetic variants in the leptin gene (LEP) were identified, with one variant significantly associated with obesity risk and altered white blood cell counts.

  • 5

    The findings suggest genetic influences on obesity-related hematological changes in the Saudi population, highlighting the need for further research.

Original Source(s)

Association between leptin gene polymorphisms and hematological metabolic parameters in obese Saudi adults

  • by Lamiaa Hamad Al-Jamea, Alexander Woodman, Rehab Yusuf Al-Ansari, Fatimah Salem Alayidh, Khalid Khalaf Alharbi, Nayef Saleh Al Ahmadi, Rashid Al-Jawair, Ibrahim Sahin, Shouq Saleh AlGhamdi, Emad Johar Al Johar, Jenifer Vecina Quiambao, Abdel Halim Deifalla, Yousef Mohammed Hawsawi

  • June 5, 2026

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