Earlier Intervention for Neurotrophic Keratitis?

New data support earlier use of decellularized basement membrane grafts in neurotrophic keratitis

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A retrospective study involving nearly 1,000 patients supports decellularized basement membrane grafts for neurotrophic keratitis intervention.
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The study published in Clinical Ophthalmology evaluated Biovance Ocular DBM grafts in patients with chronic subclinical or Mackie Stage 1 NK.
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Corneal epithelial resolution occurred in all eyes with complete follow-up, and functional corneal sensitivity improved significantly.
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Among eyes with abnormal baseline osmolarity, 70–82% normalized after treatment, and MMP-9 positivity decreased across all severity groups.
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Brandon Ayres suggests that neurotrophic keratitis is likely underdiagnosed and emphasizes the need for corneal sensitivity testing.

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