Patient-derived induced pluripotent stem cells for precision modelling of monogenic beta cell disorders

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Induced pluripotent stem cells (iPSCs) enable the study of monogenic beta cell disorders by providing patient-specific models for disease investigation.
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iPSC-derived stem cell islets (SC-islets) can model conditions like MODY and congenital hyperinsulinism, reflecting key disease mechanisms.
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Advancements in iPSC technology allow for improved genomic integrity and suitability for modeling beta cell dysfunction.
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iPSC models facilitate the exploration of genotype-phenotype relationships and the developmental contributions to monogenic beta cell disorders.
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Challenges remain in achieving complete functional maturation of SC-islets and variability in differentiation protocols, necessitating ongoing refinement.

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