ctDNA- and cfDNA-based liquid biopsy in bladder cancer and urothelial carcinoma: bibliometric mapping and cross-database coverage analysis, 2008-2025 - Takeaways - MDSpire
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Analysis of Liquid Biopsy Utilizing ctDNA and cfDNA in Bladder Cancer and Urothelial Carcinoma: A Bibliometric Review and Database Coverage Assessment from 2008 to 2025

  • By

  • Junhua Li

  • Chenhao Tang

  • Longfei Yang

  • Chen Song

  • Huixian Pan

  • September 14, 2026

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  • 1

    The study analyzes the growth and coverage of literature on ctDNA and cfDNA in bladder cancer from 2008 to 2025.

  • 2

    A total of 1,903 records were found in WoSCC, 3,201 in Scopus, and 230 in PubMed/MEDLINE, indicating varied database coverage.

  • 3

    The main set of 494 records accumulated 17,031 citations, with a peak annual output of 82 records in 2025.

  • 4

    The research highlights a shift from early methylation studies to ctDNA-based evaluations for molecular residual disease.

  • 5

    Bibliometric prominence reflects research activity rather than diagnostic accuracy or treatment benefit in bladder cancer.

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