Lytic bacteriophages active in urine against multidrug-resistant clinically derived Klebsiella pneumoniae causing urinary tract infection - Takeaways - MDSpire
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Urinary Lytic Bacteriophages Targeting Multidrug-Resistant Klebsiella pneumoniae in Urinary Tract Infections

  • By

  • Ruxandra Calin

  • Blanca Bernabeu Vilaplana

  • Judeline Gédéon

  • Estelle Capton

  • Alexis François

  • Cédric Galinat

  • Azadeh Saffarian

  • Gautier Pierrat

  • Yahia Benzerara

  • Sébastien Wurtzer

  • Laurent Moulin

  • Catherine Eckert

  • Régis Tournebize

  • September 22, 2026

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  • 1

    Urinary tract infections (UTIs) affect millions of people worldwide and are the second-leading reason for antibiotic prescriptions globally.

  • 2

    Klebsiella pneumoniae causes many UTIs in patients with underlying risk factors. Patients with neurogenic bladder face a lifelong risk of recurrent UTI.

  • 3

    Multidrug-resistant (MDR) K. pneumoniae is an increasing concern and is classified by the World Health Organization as a critical priority pathogen.

  • 4

    Bacteriophage therapy is being investigated for MDR infections, but its effectiveness for recurrent K. pneumoniae UTI is not established.

  • 5

    Researchers characterized three phages targeting a clinical MDR K. pneumoniae strain. Their lytic activity was generally stronger and more sustained in human urine than in laboratory broth.

Original Source(s)

Lytic bacteriophages active in urine against multidrug-resistant clinically derived Klebsiella pneumoniae causing urinary tract infection

  • by Ruxandra Calin, Blanca Bernabeu Vilaplana, Judeline Gédéon, Estelle Capton, Alexis François, Cédric Galinat, Azadeh Saffarian, Gautier Pierrat, Yahia Benzerara, Sébastien Wurtzer, Laurent Moulin, Catherine Eckert, Régis Tournebize

  • September 22, 2026

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