Sex specific pattern of adipose expansion, inflammation and dysfunction with short term high fat diet exposure - Takeaways - MDSpire

Sex specific pattern of adipose expansion, inflammation and dysfunction with short term high fat diet exposure

  • By

  • Julia Skibniewska

  • Symmarana Desai

  • Lucy Casell-Kelley

  • Jessica Maung

  • Abhimanyu Sastry

  • Janie McMillin

  • Heather Day

  • Kanakadurga Singer

  • Mita Varghese

  • June 23, 2026

  • 0 min

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  • 1

    Short-term high-fat diet (HFD) exposure leads to sex-specific adipose tissue remodeling in male and female mice.

  • 2

    Male mice show greater weight gain, adipocyte hypertrophy, and insulin resistance compared to female mice after HFD exposure.

  • 3

    Pro-inflammatory CD11c+ adipose tissue macrophages accumulate earlier in male mice, indicating a more pronounced inflammatory response.

  • 4

    Female mice exhibit a delayed inflammatory response and less adipocyte hypertrophy compared to males following HFD.

  • 5

    Metabolic dysfunction, including hyperinsulinemia, occurs before inflammation, particularly in male mice on a high-fat diet.

Original Source(s)

Sex specific pattern of adipose expansion, inflammation and dysfunction with short term high fat diet exposure

  • by Julia Skibniewska, Symmarana Desai, Lucy Casell-Kelley, Jessica Maung, Abhimanyu Sastry, Janie McMillin, Heather Day, Kanakadurga Singer, Mita Varghese

  • June 23, 2026

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