99mTc-FAPI-YQ3 SPECT/CT for characterizing FAPI uptake phenotypes and metabolic-stromal heterogeneity in advanced differentiated thyroid carcinoma: a prospective single-center imaging-radiomics study - Takeaways - MDSpire

99mTc-FAPI-YQ3 SPECT/CT for characterizing FAPI uptake phenotypes and metabolic-stromal heterogeneity in advanced differentiated thyroid carcinoma: a prospective single-center imaging-radiomics study

  • By

  • Peng Zhou

  • Pengjun Zhang

  • Yang Luo

  • Liang Shi

  • Jun Wang

  • Xiaochen Yao

  • Tao Qian

  • Jianhua Wang

  • Yueqing Gu

  • Feng Wang

  • July 16, 2026

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  • 1

    The study evaluated 99mTc-FAPI-YQ3 SPECT/CT for characterizing FAPI uptake and metabolic-stromal imaging in advanced differentiated thyroid carcinoma.

  • 2

    Seventeen patients with 103 lesions were analyzed, revealing a mean tumor-to-background ratio of 6.8 and various dual-tracer phenotypes.

  • 3

    99mTc-FAPI-YQ3 demonstrated high detection rates for thyroid-bed and bone lesions, but limited detection for pulmonary lesions.

  • 4

    The study found a crude concordance of 52.4% between FDG and FAPI imaging, with a Cohen kappa of -0.0955 indicating low agreement.

  • 5

    Further studies are needed to validate imaging findings with histopathologic and multi-omics approaches, as FAPI uptake is not a direct measure of FAP expression.

Original Source(s)

99mTc-FAPI-YQ3 SPECT/CT for characterizing FAPI uptake phenotypes and metabolic-stromal heterogeneity in advanced differentiated thyroid carcinoma: a prospective single-center imaging-radiomics study

  • by Peng Zhou, Pengjun Zhang, Yang Luo, Liang Shi, Jun Wang, Xiaochen Yao, Tao Qian, Jianhua Wang, Yueqing Gu, Feng Wang

  • July 16, 2026

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