Bystander and abscopal effects of boron neutron capture therapy: radiobiological mechanisms and immunotherapeutic strategies - Takeaways - MDSpire

Bystander and abscopal effects of boron neutron capture therapy: radiobiological mechanisms and immunotherapeutic strategies

  • By

  • Zizhu Zhang

  • Chunyuan Zhao

  • Yizheng Chong

  • Longmin Li

  • Xiayang Zhu

  • Yujun Shao

  • June 30, 2026

  • 0 min

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  • 1

    Boron neutron capture therapy (BNCT) selectively kills tumor cells while sparing normal tissues, utilizing a nuclear reaction between boron-10 and neutrons.

  • 2

    BNCT has shown clinical potential in treating recurrent and radioresistant cancers, with promising results reported in various tumor types.

  • 3

    Emerging evidence indicates that BNCT can induce bystander and abscopal effects, affecting non-irradiated cells and distant tumors.

  • 4

    The bystander effect involves biological responses in non-irradiated cells due to signals from irradiated neighbors, while the abscopal effect describes distant tumor regression.

  • 5

    Integrating BNCT with immunotherapy may enhance systemic antitumor immune responses, linking localized treatment effects to broader immune mechanisms.

Original Source(s)

Bystander and abscopal effects of boron neutron capture therapy: radiobiological mechanisms and immunotherapeutic strategies

  • by Zizhu Zhang, Chunyuan Zhao, Yizheng Chong, Longmin Li, Xiayang Zhu, Yujun Shao

  • June 30, 2026

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