MOG-IgG-associated encephalitis and bronchopneumonia in a child with negative infections:a case report and literature review

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MOG antibody-associated disorder (MOGAD) is a CNS demyelinating disease commonly induced by infections in children.
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A 9-year-old boy presented with fever, headache, bronchopneumonia, and encephalitis, diagnosed via imaging and lab tests.
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Positive serum MOG-IgG was found in the patient, indicating MOGAD despite negative infection results.
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Treatment included high-dose methylprednisolone and gamma globulin, leading to normalization of temperature and CSF findings.
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This case emphasizes the need for MOG-IgG testing in pediatric patients with encephalitis and bronchopneumonia.

Frontiers In Pediatrics

by Sun, Yan , Dong, Xin , Sun, Mingyue , Wang, Fei , Yu, Qing-Qing , Yan, Yibing , Cheng, Na
April 27, 2026

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