Targeting endoplasmic reticulum stress: a novel therapeutic strategy for neuropathic pain - Takeaways - MDSpire

Targeting endoplasmic reticulum stress: a novel therapeutic strategy for neuropathic pain

  • By

  • Yang Niu

  • Jiayu Han

  • Tao Song

  • Xueshu Tao

  • June 4, 2026

  • 0 min

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  • 1

    Neuropathic pain affects 7%-10% of the global population and arises from lesions in the somatosensory system.

  • 2

    Endoplasmic reticulum stress is a key mechanism in neuropathic pain, disrupting cellular homeostasis and promoting neuroinflammation.

  • 3

    The unfolded protein response (UPR) is activated by ER stress and can lead to either protective or detrimental cellular outcomes.

  • 4

    Targeting ER stress signaling presents a promising therapeutic strategy for managing neuropathic pain.

  • 5

    Cell-specific roles of ER stress in immune and glial cells contribute significantly to the development and maintenance of neuropathic pain.

Original Source(s)

Targeting endoplasmic reticulum stress: a novel therapeutic strategy for neuropathic pain

  • by Yang Niu, Jiayu Han, Tao Song, Xueshu Tao

  • June 4, 2026

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