Multimodal MRI Investigations of Cortical and Subcortical Structural Abnormalities and Their Cognitive Associations in Drug-Naïve Patients with SeLECTS - Takeaways - MDSpire

Multimodal MRI Investigations of Cortical and Subcortical Structural Abnormalities and Their Cognitive Associations in Drug-Naïve Patients with SeLECTS

  • By

  • Jiaren Zhang

  • Maoqiang Tian

  • Linfeng Song

  • Xu Chen

  • Xuejin Ma

  • Tijiang Zhang

  • Lin Jiang

  • April 16, 2026

  • 0 min

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  • 1

    SeLECTS is a common childhood epilepsy syndrome characterized by spontaneous seizure remission and frequent cognitive difficulties.

  • 2

    A multimodal MRI study on 30 drug-naïve children with SeLECTS revealed significant cortical and subcortical structural abnormalities.

  • 3

    Patients exhibited increased bilateral pontine gray matter volume and widespread cortical thinning in frontoparietal and left temporal regions.

  • 4

    Structural abnormalities correlated with clinical variables, including disease duration and verbal IQ, indicating potential cognitive impacts.

  • 5

    The findings suggest that SeLECTS involves complex neuroanatomical changes beyond the Rolandic cortex, warranting further longitudinal studies.

Original Source(s)

Multimodal MRI Investigations of Cortical and Subcortical Structural Abnormalities and Their Cognitive Associations in Drug-Naïve Patients with SeLECTS

  • by Jiaren Zhang, Maoqiang Tian, Linfeng Song, Xu Chen, Xuejin Ma, Tijiang Zhang, Lin Jiang

  • April 16, 2026

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