Pre-treatment structural brain biomarkers predict response to repetitive transcranial magnetic stimulation in subjective tinnitus - Takeaways - MDSpire
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Structural Brain Biomarkers Prior to Treatment as Predictors of Response to Repetitive Transcranial Magnetic Stimulation in Subjective Tinnitus

  • By

  • Zhongling Ding

  • Bo Peng

  • Mengfang Gong

  • Hongxuan Qiu

  • Qian He

  • Xiaoting Zhu

  • Shiyu Kang

  • Xiaoliang Sheng

  • Jisheng Liu

  • Yakang Dai

  • Duo-Duo Tao

  • June 24, 2026

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  • 1

    The study enrolled 64 patients with subjective tinnitus and 18 healthy controls to identify brain structural biomarkers predictive of rTMS efficacy.

  • 2

    Thirty-six patients (56.25%) were classified as responders to rTMS, with ten regional features distinguishing them from non-responders.

  • 3

    The predictive model achieved an AUC of 0.85, with the right pars triangularis of the inferior frontal gyrus identified as the top predictor.

  • 4

    Responders exhibited significantly larger gray matter volume in the right pars triangularis compared to healthy controls and non-responders.

  • 5

    No structural feature showed a robust correlation with clinical improvement scores or baseline clinical measures after Bonferroni correction.

Original Source(s)

Pre-treatment structural brain biomarkers predict response to repetitive transcranial magnetic stimulation in subjective tinnitus

  • by Zhongling Ding, Bo Peng, Mengfang Gong, Hongxuan Qiu, Qian He, Xiaoting Zhu, Shiyu Kang, Xiaoliang Sheng, Jisheng Liu, Yakang Dai, Duo-Duo Tao

  • June 24, 2026

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