Opposing effects of PM2.5 on TSH levels: effect modification by thyroid peroxidase antibody status in a preconception cohort - Takeaways - MDSpire

Opposing effects of PM2.5 on TSH levels: effect modification by thyroid peroxidase antibody status in a preconception cohort

  • By

  • Heze Xu

  • Yijia Liu

  • Zhijiao Wang

  • Shanwei Xing

  • Zekai Bai

  • Hang Zhen

  • Lu Ji

  • Jiapo Li

  • Chong Qiao

  • June 2, 2026

  • 0 min

Share

  • 1

    The study examined the impact of PM2.5 exposure on TSH levels in women planning pregnancy, focusing on the role of thyroid peroxidase antibody (TPOAb) status.

  • 2

    A total of 1,357 women participated, with significant interaction found between PM2.5 exposure and TPOAb status affecting TSH levels.

  • 3

    In TPOAb-negative women, increased PM2.5 exposure correlated with decreased TSH levels, while TPOAb-positive women showed increased TSH levels.

  • 4

    The effect modification by TPOAb status was specific to TSH and most pronounced for the 6-month exposure window prior to blood draw.

  • 5

    The findings suggest that TPOAb-positive women may be more susceptible to PM2.5-induced thyroid dysfunction, highlighting the need for individual susceptibility considerations.

Original Source(s)

Opposing effects of PM2.5 on TSH levels: effect modification by thyroid peroxidase antibody status in a preconception cohort

  • by Heze Xu, Yijia Liu, Zhijiao Wang, Shanwei Xing, Zekai Bai, Hang Zhen, Lu Ji, Jiapo Li, Chong Qiao

  • June 2, 2026

Related Content

The New Reality of Peptide Analysis

Kelly Broster of Thermo Fisher Scientific explains why GLP-1 peptides are exposing the limits of traditional analytical workflows

Associations between artificial light exposure during pregnancy and the risk of gestational diabetes mellitus: a prospective cohort study

A systematic review of semaglutide-associated kidney injury case reports