Factors Influencing the Timing and Administration of Postoperative Radiotherapy Following Laryngectomy for pT4 Laryngeal Carcinoma

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Postoperative radiotherapy (PORT) enhances locoregional control and survival in head and neck cancer compared to surgery alone.
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NCCN guidelines recommend initiating PORT within 6 weeks post-surgery, with delays linked to poorer oncologic outcomes.
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Approximately 49% of head and neck cancer patients in the U.S. start PORT after 6 weeks, with a mean time-to-PORT of nearly 47 days.
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Factors contributing to delays in PORT include socioeconomic and clinical variables, particularly after total laryngectomy.
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This study focuses on identifying factors associated with delayed or omitted PORT in adults with nonmetastatic pT4 laryngeal squamous cell carcinoma.

Head And Neck

by George Ashji, Arun Rajan, Elias Dahl, Sudarshan Ramanan, Nishant Chadha, Yingzhi Wu, Richard J. Wong, Marc A. Cohen, Edward Christopher Dee, Nancy Y. Lee
September 21, 2026

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