The IGF System and Aging By Cheryl A Conover Claus Oxvig October 17, 2024 0 min Endocrine Reviews Share Summary Takeaways Listen Insight Report Clinical Scorecard Quiz Poll Top Institutions 1 IGF signaling plays a crucial role in the aging process, influencing cellular senescence and age-related diseases. 2 The IGF system comprises various receptors, ligands, binding proteins, and inhibitors that regulate IGF activity in a complex manner. 3 IGF-IR mediates cell survival and differentiation, while IGF-IIR primarily functions to attenuate IGF signaling. 4 High-affinity IGF binding proteins modulate IGF action and can have context-dependent effects on cellular processes. 5 Proteolytic cleavage of IGFBPs by specific proteinases regulates IGF signaling, highlighting the intricate control of the IGF system.
