CGRP: the immune system’s double agent – context-dependent roles in inflammation, resolution and cancer - Takeaways - MDSpire

CGRP: the immune system’s double agent – context-dependent roles in inflammation, resolution and cancer

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CGRP functions as an immune 'double agent,' restraining inflammation while also driving pathological responses in various contexts.
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In innate immunity, CGRP primarily exerts anti-inflammatory effects but can promote pro-inflammatory signaling in acute high-DAMP settings.
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CGRP generally suppresses Th1 responses in adaptive immunity but enhances Th1 differentiation during acute viral infections.
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In cancer, CGRP released by tumors suppresses anti-tumor immunity and stimulates cancer cell growth.
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The review suggests repurposing anti-CGRP monoclonal antibodies for conditions driven by dysregulated CGRP signaling.

Frontiers In Immunology

Frontiers In Neurology

Frontiers In Cardiovascular Medicine

Frontiers In Medicine

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