Associations of mental health symptoms and triglyceride-glucose index with incident cardiovascular disease: a cohort study from the UK Biobank - Takeaways - MDSpire

Associations of mental health symptoms and triglyceride-glucose index with incident cardiovascular disease: a cohort study from the UK Biobank

  • By

  • Tianci Yao

  • Ying Zhu

  • Hongyu Yan

  • Qinmei Ke

  • June 24, 2026

  • 0 min

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  • 1

    The study included 250,716 UK Biobank adults free of prevalent cardiovascular disease at baseline.

  • 2

    Clear mental health symptoms (PHQ-4 ≥ 2) were associated with increased risks of incident cardiovascular disease and myocardial infarction.

  • 3

    The triglyceride-glucose index partially mediated the association between mental health symptoms and cardiovascular disease risk.

  • 4

    Significant interactions were found between high triglyceride-glucose index and clear mental health symptoms on cardiovascular disease outcomes.

  • 5

    The findings suggest that targeting insulin resistance may help reduce cardiovascular risk in individuals with clear mental health symptoms.

Original Source(s)

Associations of mental health symptoms and triglyceride-glucose index with incident cardiovascular disease: a cohort study from the UK Biobank

  • by Tianci Yao, Ying Zhu, Hongyu Yan, Qinmei Ke

  • June 24, 2026

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