Dynamic changes and clinical significance of the gut microbiota and serum metabolites in breast cancer onset, progression and chemotherapy intervention - Takeaways - MDSpire

Dynamic changes and clinical significance of the gut microbiota and serum metabolites in breast cancer onset, progression and chemotherapy intervention

  • By

  • Shuyun Jiang

  • Zhanwei Du

  • Yufei Wang

  • Hongwei Ma

  • Zhijun Ma

  • Xiaowang Wang

  • May 14, 2026

  • 0 min

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  • 1

    The study investigates the gut microbiota and serum metabolome changes from benign breast disease to breast cancer and postchemotherapy.

  • 2

    Gut microbiota diversity remained similar across groups, but significant structural differences were observed, indicating disease progression.

  • 3

    The BC group showed an increase in inflammation-associated bacteria, while the PCBC group accumulated opportunistic pathogens.

  • 4

    Metabolomic analysis revealed significant disruptions in energy and amino acid metabolism in breast cancer, with partial reconstruction postchemotherapy.

  • 5

    The integrated multiomics model effectively distinguished between disease stages, highlighting potential biomarkers for breast cancer assessment.

Original Source(s)

Dynamic changes and clinical significance of the gut microbiota and serum metabolites in breast cancer onset, progression and chemotherapy intervention

  • by Shuyun Jiang, Zhanwei Du, Yufei Wang, Hongwei Ma, Zhijun Ma, Xiaowang Wang

  • May 14, 2026

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