Metagenomic and metabolomic profiling in primary aldosteronism with coexisting obstructive sleep apnea - Takeaways - MDSpire

Metagenomic and Metabolomic Analysis in Primary Aldosteronism Associated with Obstructive Sleep Apnea

  • By

  • Li Yang

  • Yi Tao

  • Yan He

  • Shijie Liu

  • Lulu Gan

  • Anni Dai

  • Qing Ni

  • Yun Wang

  • Fengping Li

  • Qian Liu

  • Yang Hu

  • Yanqi Wang

  • Wugan Lu

  • July 20, 2026

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  • 1

    Primary aldosteronism (PA) often coexists with obstructive sleep apnea (OSA), increasing cardiometabolic risk.

  • 2

    This study analyzed gut microbiome and metabolomic profiles in 29 adults with PA stratified by OSA severity.

  • 3

    Global gut microbial diversity did not show significant differences across OSA severity groups, despite some exploratory associations.

  • 4

    Fecal metabolomic profiling revealed nominal differences related to AHI, but no significant metabolites after correction.

  • 5

    Findings suggest that gut microbiome heterogeneity in PA with OSA is reflected more by specific signals than by overall diversity.

Original Source(s)

Metagenomic and metabolomic profiling in primary aldosteronism with coexisting obstructive sleep apnea

  • by Li Yang, Yi Tao, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Qing Ni, Yun Wang, Fengping Li, Qian Liu, Yang Hu, Yanqi Wang, Wugan Lu

  • July 20, 2026

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