Transdiagnostic Patterns of Grip Strength in Schizophrenia, Current Depression, and Remitted Depression

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Reduced grip strength is observed in schizophrenia, current depression, and remitted depression compared to healthy controls.
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Grip strength is significantly lower in depression groups than in schizophrenia, with no difference between current and remitted depression.
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Negative symptoms in schizophrenia correlate with lower grip strength, particularly in avolition, affect, and alogia.
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Sex-specific analyses reveal stronger associations between symptom severity and grip strength in males compared to females.
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The study suggests grip strength may serve as a transdiagnostic biomarker for motor and motivational dysfunction in mental disorders.

Jama Psychiatry

by Sofie von Känel, Anastasia Pavlidou, Niluja Nadesalingam, Victoria Chapellier, Melanie G. Nuoffer, Lydia Maderthaner, Alexandra Kyrou, Alexios Malifatouratzis, Florian Wüthrich, Stephanie Lefebvre, Victor Pokorny, Zachary Anderson, Stewart A. Shankman, Vijay A. Mittal, Sebastian Walther
May 1, 2026

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